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元件指南

VectorBuilder提供了許多常用的載體元件，可供用戶在設(shè)計載體時進行選擇。下表按類型提供了這些常用元件的詳細信息。
CAR-T相關(guān)結(jié)構(gòu)域
姓名描述Application NotesReferences序列
CD8-leaderLeader signal peptide of T-cell surface glycoprotein CD8 alpha chainDirects transport and localization of the protein to the T-cell surface.Cell. 64:891 (1991); WO2014055771A1; US20160185862A1; US10144770B2 View
CD8-hingeHinge region of T-cell surface glycoprotein CD8 alpha chainConnects scFv and the transmembrane region; enhances tumor recognition efficiency; improves the expansion of CAR-T cells.Cell. 64:891 (1991); J Immunother. 28:203 (2005); BMJ Open. 6: e013904 (2016); J Hematol Oncol. 10: 68 (2017); Oncoimmunology. 7: e1368604 (2018) View
CD28-hingeHinge region of the T-cell surface glycoprotein CD28Connects scFv with the transmembrane region providing stability and flexibility for efficient CAR expression and function; enhances efficiency of tumor recognition; improves expansion of CAR-T cells.J Immunother. 32:689 (2009); Mol Ther. 25:2452 (2017) View
CD8-TMTransmembrane region of T-cell surface glycoprotein CD8 alpha chainAnchors the CAR to the plasma membrane and bridges the extracellular hinge as well as antigen recognition domains with the intracellular signaling region; enhances receptor expression and stability.Cell. 64:891 (1991); BMJ Open. 6: e013904 (2016); Oncoimmunology. 7: e1368604 (2018); WO2014055771A1; US20100105136A1 View
CD28-TMTransmembrane region of T-cell-surface glycoprotein CD28Anchors the CAR to the plasma membrane and bridges the extracellular hinge as well as antigen recognition domains with the intracellular signaling region; enhances receptor expression and stability.Hum Gene Ther. 24:259 (2013); Cancer Res. 74:6383 (2014); WO2014055771A1; US10144770B2 View
共刺激結(jié)構(gòu)域
姓名描述Application NotesReferences序列
CD28CD28 intracellular costimulatory domainImproves overall survival, proliferation and persistence of activated CAR-T cells.Nat Biotechnol. 20:70 (2002); J Immunother. 32:689 (2009); WO2014055771A1 View
4-1BB4-1BB intracellular costimulatory domainImproves overall survival, proliferation and persistence of activated CAR-T cells; further enhances cytotoxicity and durability when used in combination with CD28.Leukemia. 18:676 (2004); Mol Ther. 17:1453 (2009); EP2904106A2 View
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